Monkey IL-6 T cell ELISPOT antibody pair - 10-plate
SKU
CT614-10
Validated ELISPOT antibody pair; reagents available separately (960 determinations).
Species reactivity: rhesus macaque, cynomolgus monkey, pig-tailed macaque, lion-tailed macaque, baboon, mandrill, hanuman langur.
Species reactivity: rhesus macaque, cynomolgus monkey, pig-tailed macaque, lion-tailed macaque, baboon, mandrill, hanuman langur.
Format
10-plate
Price
€ 655
Documentation
Reactivity
Monkey
Category
T cell ELISPOT
Analyte
IL-6
Description
Our ELISPOT antibody pairs are validated for high assay performance using the same reagents and materials included in U-CyTech ELISPOT kits. These antibody pairs are optimized for reliable and reproducible ELISPOT assays.
The antibody pairs are available in convenient 10-plate and 20-plate format, providing 960 or 1920 determinations, respectively.
Compatible reagents for ELISPOT assays can be purchased separately, allowing customization of your ELISPOT workflow.
The antibody pairs are available in convenient 10-plate and 20-plate format, providing 960 or 1920 determinations, respectively.
Compatible reagents for ELISPOT assays can be purchased separately, allowing customization of your ELISPOT workflow.
Analyte information
Description
Interleukin-6 (IL-6) is a multifunctional cytokine produced by a wide range of cells. These include innate immune cells as macrophages, dendritic cells, and mast cells, as well as B cells, and certain CD4 effector T helper (Th) cells. In addition, non-leukocyte cells such as endothelial cells, fibroblasts, astrocytes, epithelial cells can also produce IL-6.
Although IL-6 is well known for its strong pro-inflammatory effects, it also plays an important role in regulating adaptive immunity. Specifically, IL-6 influences the balance between different T helper cell subsets. It promotes the differentiation of Th2 cells by increasing the production of IL-4 and IL-13, while simultaneously reducing IFN-γ, which is typically associated with Th1 responses. Furthermore, IL-6 contributes to the differentiation of Th17 cells when acting in combination with TGF-β. At the same time, IL-6 can inhibit the activity of regulatory T (Treg) cells in vitro. Since TGF-β alone promotes Treg cell development, the presence of IL-6 is thought to shift the balance toward Th17 cell differentiation. In this way, IL-6 plays a key role in fine-tuning the equilibrium between pro-inflammatory Th17 cells and immunosuppressive Treg cells.
Although IL-6 is well known for its strong pro-inflammatory effects, it also plays an important role in regulating adaptive immunity. Specifically, IL-6 influences the balance between different T helper cell subsets. It promotes the differentiation of Th2 cells by increasing the production of IL-4 and IL-13, while simultaneously reducing IFN-γ, which is typically associated with Th1 responses. Furthermore, IL-6 contributes to the differentiation of Th17 cells when acting in combination with TGF-β. At the same time, IL-6 can inhibit the activity of regulatory T (Treg) cells in vitro. Since TGF-β alone promotes Treg cell development, the presence of IL-6 is thought to shift the balance toward Th17 cell differentiation. In this way, IL-6 plays a key role in fine-tuning the equilibrium between pro-inflammatory Th17 cells and immunosuppressive Treg cells.
Alternative names
IL-6, Interleukin 6, interleukin-6, IL6, IFN-beta 2, IFNB2, BSF-2, BSF2, HGF, HSF, CDF, BSF-2
Gene ID
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