mAb anti-monkey CD3 (clone FN-18) - 0.5 mg

SKU
CT161
Mouse monoclonal anti-monkey CD3 antibody (IgG1).
Species reactivity: rhesus macaque, cynomolgus monkey and baboon.
Format
0.5 mg
Price
€ 470
Documentation
Data sheet
SDS
Reactivity
Monkey
Category
Antibodies
Analyte
CD3
Description
FN-18 can be used in immunohistochemistry, flow cytometric analysis and intracellular staining. In addition, it has been shown to stimulate monkey peripheral blood mononuclear cells (PBMCs).
Description
CD3 is an integral component of the TCR-CD3 complex present on the surface of T lymphocytes, where it plays an essential role in adaptive immunity. Following antigen recognition by antigen-presenting cells (APCs), activation signals generated by the T-cell receptor (TCR) are transduced across the cell membrane via the CD3δ, CD3ε, and CD3γ signaling chains, leading to T-cell activation and downstream immune responses.
Alternative names
FN-18, FN18
Gene ID
699582, 699467, 705270
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References

Authors, et al. Title Journal Year Volume Pages
Margreet Jonker Comparative analysis of inflammatory infiltrates in collagen-induced arthritis, kidney graft rejection and delayed-type hypersensitivity in non-human primates Inflamm Res 2013 62 181-94
Jung-Sik Kim Bortezomib can suppress activation of rapamycin-resistant memory T cells without affecting regulatory T-cell viability in non-human primates Transplantation 2009 88 1349-59
Luigi Aurisicchio Immunogenicity and safety of a DNA prime/adenovirus boost vaccine against rhesus CEA in nonhuman primates Int J Cancer 2007 120 2290-300
Vida Hodara Expression of CD154 by a simian immunodeficiency virus vector induces only transitory changes in rhesus macaques J Virol 2005 79 4679-90
P Frost White monkey syndrome in infant baboons (Papio species) J Med Primatol 2004 33 197-213
K Stittelaar Safety of modified vaccinia virus Ankara (MVA) in immune-suppressed macaques Vaccine 2001 19 3700-9
J Thomas Preclinical studies of allograft tolerance in rhesus monkeys: a novel anti-CD3-immunotoxin given peritransplant with donor bone marrow induces operational tolerance to kidney allografts Transplantation 1997 64 124-35
F Nooij Polymorphism for RhT3, a CD3-like cell surface antigen, expressed on rhesus monkey T lymphocytes Immunology 1986 59 611-20
F Nooij Differentiation antigens on rhesus monkey lymphocytes. I. Identification of T cells bearing CD3 and CD8, and of a subset of CD8-bearing cells Eur J Immunol 1986 16 975-9
F Nooij Differentiation antigens on rhesus monkey lymphocytes. II. Characterization of RhT3, a CD3-like antigen on T cells Eur J Immunol 1986 16 981-4