Human IL-12p70 ELISA kit - 5-plate

SKU
CT210A
All-inclusive ELISA kit with reagents and plates (480 determinations).
Format
5-plate
Price
€ 530
Documentation
Data sheet
Manual
SDS
Reactivity
Human
Category
ELISA
Analyte
IL-12p70
Range
8-512 pg/ml
Description
Our sandwich ELISA kits are developed for the determination of cytokines in culture supernatant, serum and plasma. Each kit includes all reagents required to perform up to 480 ELISA determinations: coating and detection antibodies, standards, streptavidin-HRP conjugate, TMB substrate, stop solution, cytokine stabilization buffer, BSA stock solution, ELISA plates and adhesive plate covers.
Description
Interleukin 12 (IL-12), also referred as IL-12p70, is a pro-inflammatory cytokine with a molecular weight of 70 kDa. It is composed of two subunits: IL-12p35 (35 kDa) and IL-12p40 (40 kDa). It plays a role in the immune response by inducing the differentiation of naive CD4 T cells into Th1 cells and activating natural killer (NK) cells. IL-12 is primarily produced by activated antigen-presenting cells (APC), including dendritic cells, macrophages, monocytes and B cells.
Alternative names
IL-12, IL12, Interleukin-12, Interleukin 12, IL-12p70, IL-12 p70, NKSF, NKSF1, CLMF, CMLF1, TCDF
Gene ID
3592, 3593

References

Authors, et al. Title Journal Year Volume Pages
Payal Balraadjsing The Nature of Antibacterial Adaptive Immune Responses against Staphylococcus aureus Is Dependent on the Growth Phase and Extracellular Peptidoglycan Infect Immun 2019 88
Mohsen Masjedi Cytokine Indexes in Pemphigus Vulgaris: Perception of Its Immunpathogenesis and Hopes for Non-Steroidal Treatment Iran J Pharm Res 2017 16 1223-1229
Katina Schinnerling Role of dendritic cells in the pathogenesis of Whipple's disease Infect Immun 2015 83 482-91
Janine Obendorf Increased expression of CD25, CD83, and CD86, and secretion of IL-12, IL-23, and IL-10 by human dendritic cells incubated in the presence of Toll-like receptor 2 ligands and Giardia duodenalis Parasit Vectors 2013 6 317
Mario Weinhold The Attenuated Brucella abortus Strain 19 Invades, Persists in, and Activates Human Dendritic Cells, and Induces the Secretion of IL-12p70 but Not IL-23 PLoS One 2013 8 e65934
Martin Eisenblätter Nocardia farcinica activates human dendritic cells and induces secretion of interleukin-23 (IL-23) rather than IL-12p70 Infect Immun 2012 80 4195-202
Michael Fehlings Comparative analysis of the interaction of Helicobacter pylori with human dendritic cells, macrophages, and monocytes Infect Immun 2012 80 2724-34
Mohammad Rezaee Natural oils enhance IL-10 and IFN-γ production by human PBMCs cultured with Malassezia furfur Iran J Immunol 2012 9 109-19
Abhimanyu Differential serum cytokine levels are associated with cytokine gene polymorphisms in north Indians with active pulmonary tuberculosis Infect Genet Evol 2011 11 1015-22
Hua Wang Recombinant heat shock protein 65 carrying PADRE and HBV epitopes activates dendritic cells and elicits HBV-specific CTL responses Vaccine 2011 29 2328-35