Human IL-21 T cell ELISPOT kit - 2-plate
SKU
CT419-B2
All-inclusive ELISPOT kit with reagents and plates (192 determinations).
Format
2-plate
Price
€ 485
Documentation
Reactivity
Human
Category
T cell ELISPOT
Analyte
IL-21
Description
Our ELISPOT kits provide a complete, ready-to-use solution for reliable, high-performance ELISPOT assays. Each kit includes all essential components: coating and detection antibodies, streptavidin-HRP, TMB substrate, blocking stock solution, dilution buffer, and high-quality PVDF ELISPOT plates with lids and adhesive plate covers.
Analyte information
Description
Interleukin 21 (IL-21) is a pro-inflammatory cytokine produced by several T cell subsets, including CD4 T cells, T follicular helper (Tfh) cells, and T helper 17 (Th17) cells.
IL-21 plays a key role in T cell–dependent B cell activation within germinal centers, promoting rapid B cell proliferation and their differentiation into memory B cells and long-lived plasma cells.
In addition, IL-21 supports the proliferation, differentiation, and maintenance of CD8 T cells. It enhances the cytotoxic activity of natural killer (NK) cells and contributes to the regulation of macrophage activation.
Dysregulated or excessive production of IL-21 has been linked to several inflammatory conditions, including rheumatoid arthritis, systemic lupus erythematosus (SLE), and rejection after organ transplantation.
IL-21 plays a key role in T cell–dependent B cell activation within germinal centers, promoting rapid B cell proliferation and their differentiation into memory B cells and long-lived plasma cells.
In addition, IL-21 supports the proliferation, differentiation, and maintenance of CD8 T cells. It enhances the cytotoxic activity of natural killer (NK) cells and contributes to the regulation of macrophage activation.
Dysregulated or excessive production of IL-21 has been linked to several inflammatory conditions, including rheumatoid arthritis, systemic lupus erythematosus (SLE), and rejection after organ transplantation.
Alternative names
IL-21, Interleukin-21, IL21, Interleukin 21, Za11
Gene ID
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