mAb anti-mouse IL-4 (clone 11B11) - 0.5 mg

SKU

CT324

Rat monoclonal anti-mouse IL-4 (IgG1)

Format

0.5 mg

Price

€ 315

Documentation

Data sheet

SDS

Reactivity

Mouse

Category

Antibodies

Analyte

IL-4

Description

The monoclonal antibody clone 11B11 specifically recognizes both natural and recombinant mouse IL-4. The antibody is suitable for ELISA and ELISPOT assays, in vitro neutralization, intracellular staining and Western Blot analysis.

Analyte information

Description

Interleukin-4 (IL-4) is a key cytokine that plays a central role in regulating the immune system. It is primarily produced by T helper 2 (Th2) cells, but can also be secreted by mast cells, and eosinophils and basophils. IL-4 is involved in several critical immune processes, including IgE class switching in B cell, Th2 cell differentiation, allergic inflammation and defense against parasites.

Alternative names

IL-4, Interleukin 4, Interleukin-4, IL4, BCGF-1, BGF1, BSF-1, BSF1, IL4E12

Gene ID

16189

References

Authors, et al.	Title	Journal	Year	Volume	Pages
M Haak-Frendscho	Administration of anti-IL-4 monoclonal antibody 11B11 increases the resistance of mice to Listeria monocytogenes infection	J Immunol	1992	148	3978-85
R Chatelain	IL-4 induces a Th2 response in Leishmania major-infected mice	J Immunol	1992	148	1182-7
T Mosmann	Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoadsorbent assay	J Immunol	1990	145	2938-45
H Cherwinski	Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies	J Exp Med	1987	166	1229-44
W Paul	B-cell stimulatory factor-1/interleukin 4	Annu Rev Immunol	1987	5	429-59
J Ohara	Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1	Nature	1985	315	333-6