mAb anti-rat IFN-γ (clone DB-1) - 0.5 mg

SKU
CT032
Mouse monoclonal anti-rat IFN-γ antibody (IgG1, κ).
For bulk pricing and availability, contact cs@ucytech.com.
Format
0.5 mg
Price
€ 340
Documentation
Reactivity
Rat
Category
Antibodies
Analyte
IFN-γ
Description
Clone DB-1 is a highly specific mouse monoclonal antibody against rat IFN-γ (IgG1, κ). DB-1 was capable of complete binding of both natural and recombinant rat and mouse IFN-γ. The antibody shows no cross-reactivity with IFN-α and IFN-β, or human interferons.
DB-1 is ideal for ELISA, ELISPOT, immunohistochemistry (frozen tissue) and intracellular staining.
Description
IFN-γ is a potent immune regulating cytokine that plays a central role in activating the body’s defense against infections and malignant cells. By enhancing antigen presentation and boosting the activity of T cells and natural killer (NK) cells, IFN-γ drives strong antiviral and anti tumor responses. It is primarily produced by activated T helper 1 (Th1) cells, cytotoxic T cells, γδ T cells, NK cells, and natural killer T (NKT) cells, making it a key indicator of cellular immune activation in research and diagnostic applications.
Alternative names
DB-1, DB1
IFN-γ, IFN-gamma, IFN-g, IFNg, interferon γ, interferon-γ, interferon-gamma, interferon gamma, INF-g, INF-gamma, immune interferon, Type II interferon
Image
CT101

References

Authors, et al. Title Journal Year Volume Pages
B Haagmans Suppression of rat cytomegalovirus replication by antibodies against gamma interferon J Virol 1994 68 2305-12
A Darji Inhibition of T-cell responsiveness during experimental infections with Trypanosoma brucei: active involvement of endogenous gamma interferon Infect Immun 1993 61 3098-102
G Stoll Localization of interferon-gamma and Ia-antigen in T cell line-mediated experimental autoimmune encephalomyelitis Am J Pathol 1993 142 1866-75
B Schmidt Transient cellular expression of gamma-interferon in myelin-induced and T-cell line-mediated experimental autoimmune neuritis Brain 1992 115 ( Pt 6) 1633-46
M Mustafa T cell immunity and interferon-gamma secretion during experimental allergic encephalomyelitis in Lewis rats J Neuroimmunol 1991 31 165-77
A Rosenberg Specific prolongation of MHC class II disparate skin allografts by in vivo administration of anti-IFN-gamma monoclonal antibody J Immunol 1990 144 4648-50
I Nennesmo Interferon-gamma-like immunoreactivity and T-cell marker expression in rat skeletal muscle fibres Brain Res 1989 504 306-10
A Ljungdahl Interferon-gamma-like immunoreactivity in certain neurons of the central and peripheral nervous system J Neurosci Res 1989 24 451-6
P van der Meide Isolation and characterization of monoclonal antibodies directed to rat interferon-gamma Lymphokine Res 1989 8 439-49
P van der Meide The purification and characterization of rat gamma interferon by use of two monoclonal antibodies J Gen Virol 1986 67 ( Pt 6) 1059-71