Monkey IL-12/IL-23 p40 ELISA antibody pair - 10-plate

SKU
CT719-10
Validated ELISA antibody pair with standard and conjugate; reagents available separately (960 determinations).
Species reactivity: rhesus macaque, cynomolgus monkey, pig-tailed macaque, baboon, African green monkey.

Format
10-plate
Price
€ 625
Reactivity
Monkey
Category
ELISA
Analyte
IL-12/IL-23 p40
Description
Our ELISA antibody pairs are extensively validated for high assay performance using the same reagents and materials included in U-CyTech ELISA kits. These antibody pairs are optimized to ensure reliable, sensitive, and reproducible results in a wide range of ELISA applications.
The ELISA antibody pairs are available in convenient 10- or 20-plate formats, providing 960 or 1920 determinations, respectively. Each set is supplied with either 5 or 10 vials of standards and 2 or 4 vials of Streptavidin-HRP conjugate, offering flexibility for different experimental needs and throughput requirements.
Designed for ease of use and consistent performance, these ELISA reagents support accurate quantification in immunoassays. Additional ELISA plates and reagents can be purchased separately, allowing customization of your ELISA workflow.
Description
Interleukin 12 (IL-12) is a pro-inflammatory cytokine with a molecular weight of 70 kDa, composed of two subunits: IL-12p35 (35 kDa) and IL-12p40 (40 kDa). It plays a role in the immune response by inducing the differentiation of naive CD4 T cells into Th1 cells and activating natural killer (NK) cells. IL-12 is primarily produced by activated antigen-presenting cells (APC), including dendritic cells, macrophages, monocytes and B cells.
Interleukin 23 (IL-23) promotes the expansion of Th17 cell cells. It is also heterodimeric cytokine composed of the IL-12p40 subunit and a unique p19 subunit. IL-23 is mainly secreted by macrophages and dendritic cells.
Because both IL-12 and IL-23 heterodimers share the p40 subunit, immunoassays targeting p40 will detect both cytokines.
Alternative names
IL-12, IL12, Interleukin 12, Interleukin-12, IL-12p40, IL-23, IL-12B, IL-12B, CLMF p40, NKSF, TSF
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References

Authors, et al. Title Journal Year Volume Pages
Naomi Logsdon Design and analysis of rhesus cytomegalovirus IL-10 mutants as a model for novel vaccines against human cytomegalovirus PLoS One 2011 6 e28127
Y Qiu Comparison of immunological responses of plague vaccines F1+rV270 and EV76 in Chinese-origin rhesus macaque, Macaca mulatta Scand J Immunol 2010 72 425-33
Yolanda Kap Late B cell depletion with a human anti-human CD20 IgG1κ monoclonal antibody halts the development of experimental autoimmune encephalomyelitis in marmosets J Immunol 2010 185 3990-4003
Céline van der Putten Differential expression of adenosine A3 receptors controls adenosine A2A receptor-mediated inhibition of TLR responses in microglia J Immunol 2009 182 7603-12
Christiane Stahl-Hennig Synthetic double-stranded RNAs are adjuvants for the induction of T helper 1 and humoral immune responses to human papillomavirus in rhesus macaques PLoS Pathog 2009 5 e1000373
Jeff Fairman Enhanced in vivo immunogenicity of SIV vaccine candidates with cationic liposome-DNA complexes in a rhesus macaque pilot study Hum Vaccin 2009 5 141-50
David Favre Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection PLoS Pathog 2009 5 e1000295
Anwar Jagessar Autoimmunity against myelin oligodendrocyte glycoprotein is dispensable for the initiation although essential for the progression of chronic encephalomyelitis in common marmosets J Neuropathol Exp Neurol 2008 67 326-40
Lizette Visser Phagocytes containing a disease-promoting Toll-like receptor/Nod ligand are present in the brain during demyelinating disease in primates Am J Pathol 2006 169 1671-85
Koen Van Rompay Structured treatment interruptions with tenofovir monotherapy for simian immunodeficiency virus-infected newborn macaques J Virol 2006 80 6399-410