Monkey IL-12/IL-23 p40 ELISA kit - 5-plate

SKU
CT149A
All-inclusive ELISA kit with reagents and plates (480 determinations).
Species reactivity: rhesus macaque, cynomolgus monkey, pig-tailed macaque, baboon, African green monkey.
Format
5-plate
Price
€ 530
Documentation
Data sheet
Manual
SDS
Reactivity
Monkey
Category
ELISA
Analyte
IL-12/IL-23 p40
Range
8-512 pg/ml
Description
Our sandwich ELISA kits are developed for the determination of cytokines in culture supernatant, serum and plasma. Each kit includes all reagents required to perform up to 480 ELISA determinations: coating and detection antibodies, standards, streptavidin-HRP conjugate, TMB substrate, stop solution, cytokine stabilization buffer, BSA stock solution, ELISA plates and adhesive plate covers.
Description
Interleukin 12 (IL-12) is a pro-inflammatory cytokine with a molecular weight of 70 kDa, composed of two subunits: IL-12p35 (35 kDa) and IL-12p40 (40 kDa). It plays a role in the immune response by inducing the differentiation of naive CD4 T cells into Th1 cells and activating natural killer (NK) cells. IL-12 is primarily produced by activated antigen-presenting cells (APC), including dendritic cells, macrophages, monocytes and B cells.
Interleukin 23 (IL-23) promotes the expansion of Th17 cell cells. It is also heterodimeric cytokine composed of the IL-12p40 subunit and a unique p19 subunit. IL-23 is mainly secreted by macrophages and dendritic cells.
Because both IL-12 and IL-23 heterodimers share the p40 subunit, immunoassays targeting p40 will detect both cytokines.
Alternative names
IL-12, IL12, Interleukin 12, Interleukin-12, IL-12p40, IL-23, IL-12B, IL-12B, CLMF p40, NKSF, TSF
Gene ID
694747

References

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David Favre Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection PLoS Pathog 2009 5 e1000295
Anwar Jagessar Autoimmunity against myelin oligodendrocyte glycoprotein is dispensable for the initiation although essential for the progression of chronic encephalomyelitis in common marmosets J Neuropathol Exp Neurol 2008 67 326-40
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Koen Van Rompay Structured treatment interruptions with tenofovir monotherapy for simian immunodeficiency virus-infected newborn macaques J Virol 2006 80 6399-410