pAb rabbit anti-human IL-12p70 (affinity purified) - 0.5 mg

SKU
CT273
Rabbit polyclonal antibody to human IL-12p70
Format
0.5 mg
Price
€ 300
Documentation
Data sheet
SDS
Reactivity
Human
Category
Antibodies
Analyte
IL-12p70
Description
The affinity-purified rabbit polyclonal antibody specifically binds to and neutralizes human and rhesus monkey IL-12p70, including both natural and recombinant IL-12p70. It can be used to inhibit IL-12 activity and induce Th2 polarization. The antibody is suitable for use in ELISA and ELISPOT assays and Western blot analysis.
Description
Interleukin-12 (IL-12), also referred as IL-12p70, is a pro-inflammatory cytokine with a molecular weight of 70 kDa. It is composed of two subunits: IL-12p35 (35 kDa) and IL-12p40 (40 kDa). It plays a role in the immune response by inducing the differentiation of naive CD4 T cells into Th1 cells and activating natural killer (NK) cells. IL-12 is primarily produced by activated antigen-presenting cells (APC), including dendritic cells, macrophages, monocytes and B cells.
Alternative names
IL-12, IL12, Interleukin-12, Interleukin 12, IL-12p70, IL-12 p70, NKSF, NKSF1, CLMF, CMLF1, TCDF
Gene ID
3592, 3593

References

Authors, et al. Title Journal Year Volume Pages
Edwin Heeregrave Glycan dependent phenotype differences of HIV-1 generated from macrophage versus CD4+ T helper cell populations Front Immunol 2023 14 1107349
Astrid van Beelen Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells Immunity 2007 27 660-9
B Kapitein The interleukin-10 inducing effect of transforming growth factor-beta on human naive CD4+ T cells from cord blood is restricted to the TH1 subset Clin Exp Immunol 2007 147 352-8
Fedde Groot Differential susceptibility of naïve, central memory and effector memory T cells to dendritic cell-mediated HIV-1 transmission Retrovirology 2006 3 52
Lianne Wassink ICOS expression by activated human Th cells is enhanced by IL-12 and IL-23: increased ICOS expression enhances the effector function of both Th1 and Th2 cells J Immunol 2004 173 1779-86
Hermelijn Smits Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development Eur J Immunol 2004 34 1371-80
Jean-Pierre Bayley Allele-specific expression of the IL-1 alpha gene in human CD4+ T cell clones J Immunol 2003 171 2349-53
Jean-Pierre Bayley Analysis of allelic expression patterns of IL-2, IL-3, IL-4, and IL-13 in human CD4+ T cell clones Eur J Immunol 2003 33 2142-8
Emil Boonacker CD26/DPPIV signal transduction function, but not proteolytic activity, is directly related to its expression level on human Th1 and Th2 cell lines as detected with living cell cytochemistry J Histochem Cytochem 2002 50 1169-77
Hermelijn Smits Intercellular adhesion molecule-1/LFA-1 ligation favors human Th1 development J Immunol 2002 168 1710-6