Monkey IL-12/IL-23 p40 ELISA kit - 5-plate

SKU
CT149A
All-inclusive ELISA kit with reagents and plates (480 determinations).
Species reactivity: rhesus macaque, cynomolgus monkey, pig-tailed macaque, baboon, African green monkey.
Format
5-plate
Price
€ 530
Documentation
Data sheet
Manual
SDS
Reactivity
Monkey
Category
ELISA
Analyte
IL-12/IL-23 p40
Range
8-512 pg/ml
Description
Our sandwich ELISA kits are developed for the determination of cytokines in culture supernatant, serum and plasma. Each kit includes all reagents required to perform up to 480 ELISA determinations: coating and detection antibodies, standards, streptavidin-HRP conjugate, TMB substrate, stop solution, cytokine stabilization buffer, BSA stock solution, ELISA plates and adhesive plate covers.
Description
Interleukin 12 (IL-12) is a pro-inflammatory cytokine with a molecular weight of 70 kDa, composed of two subunits: IL-12p35 (35 kDa) and IL-12p40 (40 kDa). It plays a role in the immune response by inducing the differentiation of naive CD4 T cells into Th1 cells and activating natural killer (NK) cells. IL-12 is primarily produced by activated antigen-presenting cells (APC), including dendritic cells, macrophages, monocytes and B cells.
Interleukin 23 (IL-23) promotes the expansion of Th17 cell cells. It is also heterodimeric cytokine composed of the IL-12p40 subunit and a unique p19 subunit. IL-23 is mainly secreted by macrophages and dendritic cells.
Because both IL-12 and IL-23 heterodimers share the p40 subunit, immunoassays targeting p40 will detect both cytokines.
Alternative names
IL-12, IL12, Interleukin 12, Interleukin-12, IL-12p40, IL-23, IL-12B, IL-12B, CLMF p40, NKSF, TSF
Gene ID
694747

References

Authors, et al. Title Journal Year Volume Pages
Clarah Jebet Roles of cytokines in modulating Trypanosoma brucei rhodesiense infection outcomes in vervet monkeys Front Parasitol 2025 4 1725651
Raissa Timmerman P2Y6 receptor-mediated signaling amplifies TLR-induced pro-inflammatory responses in microglia Front Immunol 2022 13 967951
Ella Zuiderwijk-Sick Exposure of Microglia to Interleukin-4 Represses NF-κB-Dependent Transcription of Toll-Like Receptor-Induced Cytokines Front Immunol 2021 12 771453
Mingqian Li Induction of porcine-specific regulatory T cells with high specificity and expression of IL-10 and TGF-β1 using baboon-derived tolerogenic dendritic cells Xenotransplantation 2018 25
Elizabeth Wonderlich Macrophages and Myeloid Dendritic Cells Lose T Cell-Stimulating Function in Simian Immunodeficiency Virus Infection Associated with Diminished IL-12 and IFN-α Production J Immunol 2015 195 3284-92
Béatrice Jacquelin Innate immune responses and rapid control of inflammation in African green monkeys treated or not with interferon-alpha during primary SIVagm infection PLoS Pathog 2014 10 e1004241
Kristin Trott Immune activation and regulation in simian immunodeficiency virus-Plasmodium fragile-coinfected rhesus macaques J Virol 2013 87 9523-37
Joseph Brown Morphine produces immunosuppressive effects in nonhuman primates at the proteomic and cellular levels Mol Cell Proteomics 2012 11 605-18
Céline Van Der Putten Statins amplify TLR-induced responses in microglia via inhibition of cholesterol biosynthesis Glia 2012 60 43-52
Meghan Eberhardt Host immune responses to a viral immune modulating protein: immunogenicity of viral interleukin-10 in rhesus cytomegalovirus-infected rhesus macaques PLoS One 2012 7 e37931