mAb anti-human IFN-γ (clone MD-2) - 0.5 mg

SKU
CT216
Mouse monoclonal anti-human IFN-γ antibody (IgG1)
Format
0.5 mg
Price
€ 315
Documentation
Reactivity
Human
Category
Antibodies
Analyte
IFN-γ
Description
MD-2 is a monoclonal antibody specific for human IFN-γ that recognizes both natural and recombinant IFN-γ with high affinity. The antibody is non-neutralizing in antiviral bioassays and is suitable for ELISA assays. No reactivity has been observed with mouse or rat IFN-γ, human IFN-α, or human IFN-ß.
Description
IFN-γ is a potent immune regulating cytokine that plays a central role in activating the body’s defense against infections and malignant cells. By enhancing antigen presentation and boosting the activity of T cells and natural killer (NK) cells, IFN-γ drives strong antiviral and anti tumor responses. It is primarily produced by activated T helper 1 (Th1) cells, cytotoxic T cells, γδ T cells, NK cells, and natural killer T (NKT) cells, making it a key indicator of cellular immune activation in research and diagnostic applications.
Alternative names
MD-2, MD2
IFN-γ, IFN-gamma, IFN-g, IFNg, interferon γ, interferon-γ, interferon-gamma, interferon gamma, INF-g, INF-gamma, immune interferon, Type II interferon
Image
CT101

References

Authors, et al. Title Journal Year Volume Pages
Lisa Vogelpoel Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages Nat Commun 2014 5 5444
Jaap van Dissel Ag85B-ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in volunteers with previous BCG vaccination or tuberculosis infection Vaccine 2011 29 2100-9
Jaap van Dissel Ag85B-ESAT-6 adjuvanted with IC31 promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naïve human volunteers Vaccine 2010 28 3571-81
Yolanda Kap A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates J Histochem Cytochem 2009 57 1159-67
E Stigter Development of an on-line SPR-digestion-nanoLC-MS/MS system for the quantification and identification of interferon-gamma in plasma Biosens Bioelectron 2009 24 2184-90
E Stigter An improved coating for the isolation and quantitation of interferon-gamma in spiked plasma using surface plasmon resonance (SPR) Biosens Bioelectron 2005 21 474-82
Thjon Tang Intrahepatic CD8+ T-lymphocyte response is important for therapy-induced viral clearance in chronic hepatitis B infection J Hepatol 2005 43 45-52
M Bart On the response of a label-free interferon-gamma immunosensor utilizing electrochemical impedance spectroscopy Biosens Bioelectron 2005 21 49-59
Herbert Brok Prevention of experimental autoimmune encephalomyelitis in common marmosets using an anti-IL-12p40 monoclonal antibody J Immunol 2002 169 6554-63
J Laman Expression of accessory molecules and cytokines in acute EAE in marmoset monkeys (Callithrix jacchus) J Neuroimmunol 1998 86 30-45