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Clinical and immunological features of very long-term survivors with a single renal transplant.
Bererhi, Lynda
Pallet, Nicolas
Zuber, Julien
Anglicheau, Dany
Kreis, Henri
Legendre, Christophe
Candon, Sophie
Transplant international : official journal of the European Society for Organ Transplantation 2012 May;25: 545-54

The aim of this study was to analyze the clinical and immunological features of the 56 still alive patients at our institution harboring a functional first renal transplant since more than 30 years. The mean post-transplant graft survival in all patients was 35.4 ± 3.1 years, the mean serum creatinine concentration was 128.7 ± 7 μmol/l, and the mean urinary protein concentration was 0.6 ± 0.5 g/l. Fifty-one percent of the patients had experienced cancer involving the skin (46.1%) and/or other tissues (28%). Hepatocarcinoma was diagnosed in 11% of the patients with chronic viral hepatitis B and/or C (48%). The 5-year patient survival rate (considered after the 30th transplantation anniversary) was 27% in patients presenting a tumor versus 87% in those tumor-free (P

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