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Year Reference
2007 A single-nucleotide synonymous mutation in the gag gene controlling human immunodeficiency virus type 1 virion production. Hamano T, Matsuo K, Hibi Y, Victoriano AFB, Takahashi N, Mabuchi Y, Soji T, Irie S, Sawanpanyalert P, Yanai H, Hara T, Yamazaki S, Yamamoto N, Okamoto T J. Virol. 2007 Feb;81: 1528-33

Abstract

Viral factors as well as host ones play major roles in the disease progression of human immunodeficiency virus type 1 (HIV-1) infection. We have examined cytotoxic T-lymphocyte activity and HIV-1 DNA PCR results of 312 high-risk seronegative drug users in northern Thailand and identified four seronegative cases positive for both assays. Furthermore, we have identified a synonymous mutation in nucleotide position 75 of the gag p17 gene (A426G) of HIV-1 that belongs to the CRF01_AE virus circulating in Thailand. The replication-competent HIV-1 clone containing the A426G mutation demonstrated a dramatic reduction of virion production and perturbation of viral morphogenesis without affecting viral protein synthesis in cells.