Figure This is a crystal structure of human IL-2 as published by Arkin et al. and created using the data from Protein Data Bank (PDB: 1M47) and rendered using PyMOL.
IL-2 is a cytokine that induces the proliferation of responsive T cells. In addition, it acts on some B cells, via receptor-specific binding, as a growth factor and antibody production stimulant. The protein is secreted as a single glycosylated polypeptide, and cleavage of a signal sequence is required for its activity. Solution NMR suggests that the structure of IL-2 comprises a bundle of 4 helices (termed A-D), flanked by shorter helices and several poorly defined loops. Residues in helix A, and in the loop region between helices A and B, are important for receptor binding. Secondary structure analysis has suggested similarity to IL-4 and granulocyte-macrophage colony stimulating factor (GM-CSF).
Detecting IL-2 with U-CyTech products
Human IL-2 ELISA
Old World Monkey IL-2 ELISA
New World Monkey IL-2 ELISA (marmoset)
Mouse IL-2 ELISA
T cell ELISPOT products
Human IL-2 ELISPOT
Old World Monkey IL-2 ELISPOT
Human IFN-γ/IL-2 FluoroSpot
Old World Monkey IFN-γ/IL-2 FluoroSpot