Interleukin 33 (IL-33) is an alarmin cytokine and belongs to the IL-1 family. It is released upon tissue injury. IL-33 plays a crucial role in allergy inflammation, viral respiratory infections, COVID-19, inflammatory bowel diseases, cancer and infections e.g. hepatitis B and C viruses, CMV and HIV.
IL-33 is released by damaged endothelial and epithelial cells at barrier sites to trigger mast cells, basophils, dendritic cells, macrophages and innate lymphoid cells (ILC2). IL-33 is involved in the innate and adaptive immune response by activating natural killers cells, Th1 and Th2 cells and cytotoxic T lymphocytes. The biologically active form of IL-33 binds to a receptor complex composed of ST2 and IL-1RAcP.
Detecting IL-33 with U-CyTech products