Reference Database

Impaired T lymphocyte responses during childhood Staphylococcus aureus infection.
Li, Zhaotao
Beesetty, Pavani
Gerges, George
Kleinhenz, Maureen
Moore-Clingenpeel, Melissa
Yang, Ching
Ahmed, Luul B
Hensley, Josey
Steele, Lisa
Chong, Anita S
Montgomery, Christopher P
J Infect Dis 2022 Jan 5;225(1): 177-185

BACKGROUND: Staphylococcus aureus infections are common throughout the lifespan, with recurrent infections occuring in nearly half of infected children. There is no licensed vaccine, underscoring the need to better understand how S. aureus evades protective immunity. Despite much study, the relative contributions of antibodies and T cells to protection against S. aureus infections in humans are not fully understood.

METHODS: We prospectively quantified S. aureus-specific antibody levels by ELISA and T cell responses by ELISpot in S. aureus-infected and healthy children.

RESULTS: S. aureus-specific antibody levels and T cell responses increased with age in healthy children, suggesting a coordinated development of anti-staphylococcal immunity. Antibody levels against leukotoxin E (LukE) and Panton-Valentine leukocidin (LukS-PV), but not α-hemolysin (Hla), were higher in younger infected children, compared with healthy children; these differences disappeared in older children. We observed a striking impairment of global and S. aureus-specific T cell function in children with invasive and non-invasive infection, suggesting that S. aureus-specific immune responses are dysregulated during childhood infection regardless of the infection phenotype.

CONCLUSIONS: These findings identify a potential mechanism by which S. aureus infection actively evades adaptive immune responses, thereby preventing the development of protective immunty and maintaining susceptibility to recurrent infection.

Forward to a friend