Catalogue Number
CT273
Description
pAb rabbit anti-human IL-12p70 (affinity pur.) - 0.5 mg
Price
€ 255.00
Characteristics
affinity purified
Summary
The polyclonal antibody to human IL-12p70 neutralizes both natural and recombinant human and rhesus macaque IL-12 and IL-23 (van Beelen A.J. et al. 2007). The antibody has been used to skew Th2 polarization by blocking IL-12 which normally induces IFN-gamma production and stimulation of PBMC (Groot F. et al. 2006 and Kaptein B. et al. 2007). The antibody is suitable for ELISA and ELISPOT assays and is affinity purified.
References list
- Differential susceptibility of naïve, central memory and effector memory T cells to dendritic cell-mediated HIV-1 transmission.
- The interleukin-10 inducing effect of transforming growth factor-beta on human naive CD4+ T cells from cord blood is restricted to the TH1 subset.
- IL-12-induced reversal of human Th2 cells is accompanied by full restoration of IL-12 responsiveness and loss of GATA-3 expression.
- Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells.